Curriculum Vitae: Arthur Sherman
Address
N.I.H.N.I.D.D.K.L.B.M.
Building 12A, Room 4007, MSC 5621
Bethesda, MD 208925621
phone: (301) 496  4325
fax: (301) 402  0535
email: arthurs@niddk.nih.gov
Education
Cornell University, B. A. Mathematics, June, 1973
New York University, M. S. Mathematics, June, 1983
New York University, Ph. D. Mathematics, October, 1986
Employment
9/79  6/81 Mathematics teacher, Emerson High School, Union City,
New Jersey.
9/81  6/86 Graduate Teaching Assistant and Adjunct Mathematics
Instructor, New York University.
9/86  9/89 National Research Council  National Institutes of
Health Research Associate.
9/89  7/96 N. I. H. Senior Staff Fellow, Mathematical Research
Branch, N.I.D.D.K.
7/96  Present Senior Investigator (Research Mathematician), Mathematical Research
Branch/Laboratory of Biological Modeling, N.I.D.D.K.
2/05  Present Chief, Laboratory of Biological Modeling, N.I.D.D.K.
8/11 Appointed to Senior Biomedical Research Service.
Honors
2018 Elected a fellow of the Society for Industrial and Applied Mathematics
[SIAM]
2019 Awarded the Arthur T. Winfree Prize for theoretical work that has inspired significant new biology
[SMB]
Refereed Articles

S. M. Briker, T. Hormenu, C. W. DuBose, L. S. Mabundo, S. T. Chung, J. Ha, A. Sherman, M. K. TullochReid, M. Bergman, A. E. Sumner. 2020.
Metabolic characteristics of Africans with normal glucose tolerance and elevated 1hour glucose: insight from the Africans in America study.
BMJ Open Diabetes Research and Care. 8(1):e000837.
[PubMed]

M. M. Janjic, R. M. Prévide, P. A. Fletcher, A. Sherman, K. Smiljanic, D. Abebe, I. Bjelobaba, and S. S. Stojilkivic. 2019.
Divergent expression patterns of pituitary gonadotropin subunit and GnRH receptor genes to continuous GnRH in vitro and in vivo.
Sci. Rep. 9(1):20098.
[PubMed]

R. T. Scarl, K. L. Corbin, N. W. Vann, H. M. Smith, L. S. Satin, A. Sherman, C. S. Nunemaker. 2019. Intact pancreatic islets and dispersed betacells both generate intracellular calcium oscillations but differ in their responsiveness to glucose. Cell Calcium. 83:102081.
[PubMed]

P. A. Fletcher, K. Smiljanic, R. Maso Prévide, J. Iben, T. Li, M. B. Rokic, A. Sherman, S. L. Coon, and S. S. Stojilkovic. 2019.
Cell Type and SexDependent Transcriptome Profiles of Rat Anterior Pituitary Cells.
Front. Endocrinol. 10:623.
[PubMed]

S. Briker, J. Aduwo, R. Mugeni, M. F. HorlyckRomanovsky, C. DuBose, L. Mabundo, T. Hormenu, S. T. Chung, J. Ha, A. Sherman, and A. E. Sumner. 2019.
A1C Underperforms as a Diagnostic Test in Africans even in the Absence of Nutritional Deficiencies, Anemia and Hemoglobinopathies: Insight from the Africans in America Study.
Front. Endocrinol., Volume 10, Article 533.
[PubMed]
[The Paper (Open Access)]

S. T. Chung, M. GalvanDe La Cruz, P. C. Aldana, L. S. Mabundo,
C. W. DuBose, A. U. Onuzuruike, M. Walter, A. M. Gharib, A. B. Courville,
A. S. Sherman, A. E. Sumner. 2019.
Postprandial insulin response and clearance among black and white women: The
Federal Women's Study.
J. Clin. Endocrinol. Metab., 104(1):181192.
[PubMed]
[Commentary]

S. T. Chung, J. Ha, A. U. Onuzuruike, K. Kasturi, M. Galvan De La Cruz, B. A. Bingham,
R. L. Baker, J. N. Utumatwishima, L. S. Mabundo, M. Ricks, A. S. Sherman, A. E. Sumner. 2017.
Time to Glucose Peak is a Better Indicator of Prediabetes
and βcell function than Shape of the Glucose Curve.
Clin. Endocrinol., 87(5):484491.
[PubMed]

L. Mackay, H. Zemkova, S. S. Stojilkovic, A. Sherman, and A. Khadra. 2017.
Deciphering the Regulation of P2X4 Receptor Channel Gating by Ivermectin using Markov Models.
PLoS Comp. Biol., 13(7):e1005643.
[PubMed]

C. H. Ahn, S. H. Min, D.W. Lee, T. J. Oh, K. M. Kim, J. H. Moon, S. H. Choi, K. S. Park, H. C. Jang, J. Ha and A. Sherman, and S. Lim. 2017.
Hemoglobin Glycation Index Is Associated with Cardiovascular Diseases in People with Impaired Glucose Metabolism.
J. Clin. Endocrinol. Metab., 102(8):29052913.
[PubMed]

J. Ha and A. S. Sherman. 2017.
How Adaptation Makes Low Firing Rates Robust.
J. Math. Neurosci., 7:4.
[PubMed]
[The Paper (Open Access)]
[xpp files (GitHub)]

N. R. Gandasi, P. Yin, M. Riz, M. V. Chibalina, G. Cortese, P.E. Lund, V. Matveev, P. Rorsman, A. Sherman, M. G. Pedersen, and S. Barg. 2017.
Ca^{2+} channel clustering with insulincontaining granules is disturbed in type 2 diabetes.
J. Clin. Invest., 127(6):23532364.
[PubMed]

P. A. Fletcher, H. Zemkova, S. S. Stojilkovic, and A. Sherman. 2017.
Modeling the diversity of spontaneous and agonistinduced electrical activity in anterior pituitary corticotrophs.
J. Neurophysiol., 117(6):22982311.
[PubMed]

M. Watts, J. Ha, O. Kimchi, and A. Sherman. 2016.
Paracrine Regulation of Glucagon Secretion: The βαδ Model.
Am. J. Physiol. (Endocrinol. Metab.), 310:E597E611.
[PubMed]
[XPP Files]

J. P. McKenna, J. Ha, M. J. Merrins, L. S. Satin, A. Sherman, and R. Bertram. 2016.
Ca^{2+} Effects on ATP Production and Consumption Have Key
Regulatory Roles on Oscillatory Islet Activity.
Biophys. J., 110(3):733742.
[PubMed]
[XPP Files]

M. J. Merrins, C. Poudel, J. P. McKenna, J. Ha, A. Sherman, R. Bertram, and L. S. Satin. 2016.
Phase Analysis of Metabolic Oscillations and Membrane Potential in Pancreatic Islet βcells.
Biophys. J., 110(3):691699.
[PubMed]

J. Ha, L. S. Satin and A. S. Sherman. 2016.
Mathematical Model of the Pathogenesis, Prevention and Reversal of Type 2 Diabetes.
Endocrinology, 157(2):624635.
[PubMed]
[XPP Files]

E. Glynn, B. Thompson, S. Lu, S. Vadrevu, R. T. Kennedy, J. Ha,
A. Sherman and L. S. Satin. 2016.
Chronic glucose exposure systematically shifts the oscillatory threshold of mouse islets:
Experimental evidence for an early intrinsic mechanism of compensation for hyperglycemia.
Endocrinology, 157(2):611623.
[PubMed]

B. E. Peercy, A. S. Sherman and R. Bertram. 2015.
Modeling of glucoseinduced cAMP oscillations in pancreatic βcells:
cAMP rocks when metabolism rolls.
Biophys. J., 109(2):43949.
[PubMed]
[XPP Files (also at journal site)]

H. Zemkova, A. Khadra, M. B. Rokic, V. Tvrdonova, A. Sherman and S. S. Stojilkovic. 2015.
Allosteric Regulation of the P2X4 Receptor Channel Pore Dilation.
Eur. J. Neurosci. (Pflügers Arch.),
467(4):713726.
[PubMed]

B. Eliasson, U. Smith, S. Mullen, S. W. Cushman, A. S. Sherman and J. Yang. 2014.
Amelioration of insulin resistance by rosiglitazone is associated with increased adipose cell size in obese type 2 diabetic patients,
Adipocyte 3(4):314321.
[PubMed]

M. Watts, B. Fendler, M. J. Merrins, L. S. Satin, R. Bertram, and A. Sherman. 2014.
Calcium and metabolic oscillations in pancreatic islets: Who's driving the bus?
SIAM J. Appl. Dyn. Syst. 13(2):683703.
[PubMed]
[Journal]
[XPP and Animation Files]
[pdf]

T. McLaughlin, C. Lamendola, N. Coghlan, T. Liu, K. Lerner, A. Sherman, and S. W. Cushman. 2014.
Adipose cell size and distribution: Relationships to insulin resistance, body fat, and sex. Obesity, 22(3):67380.
[PubMed]

M. Watts, and A. Sherman. 2014.
Modeling the pancreatic alphacell: Dual mechanisms of glucose suppression of glucagon secretion,
Biophys. J., 106:741751.
[PubMed]
[XPP Files]

J. Ren, A. Sherman, R. Bertram, P. B. Goforth, L. S. Satin, C. Waters and C. Nunemaker. 2013.
Slow oscillations of KATP conductance in mouse pancreatic islets provide support for electrical bursting driven by metabolic oscillations.
Am. J. Physiol. (Endocrinol. and Metab.), 305(7):E80517.
[PubMed]
[XPP and Matlab Files]

A. Khadra, M. Tomić, Z. Yan, H. Zemkova, A. Sherman, and S. S. Stojilkovic. 2013.
Dual gating mechanism and function of P2X7 receptor channels,
Biophys. J., 104(12):26122621.
[PubMed]

M. J. Merrins, R. Bertram, A. Sherman, and L. S. Satin. 2012.
Phosphofructo2kinase/Fructose2,6bisphosphatase Modulates Oscillations of Pancreatic Islet Metabolism,
PLoS One, 7(4):e34036.
[PubMed]
[XPP Files]

A. Khadra, Z. Yan, C. Coddou, M. Tomić, A. Sherman, and S. S. Stojilkovic. 2012.
Gating properties of the P2X2a and P2X2b receptor channels: Experiments and mathematical modeling.
J. Gen. Physiol., 139(5):333348.
[PubMed]

J. Yang, B. Eliasson, U. Smith, S. W. Cushman, and A. Sherman. 2012.
The size of large adipose cells is a predictor of insulin resistance in firstdegree relatives of type
2 diabetic patients.
Obesity, 20(5):932938.
[PubMed]

H. M. Osinga, A. Sherman, and K. TsanevaAtanasova. 2012.
Crosscurrents between biology and mathematics: The codimension of
pseudoplateau bursting.
Discrete and Continuous Dynamical Systems A, 32(8):28532877.
[Special Issue of Journal]

Z. Yan, A. Khadra, A. Sherman, and S. S. Stojilkovic. 2011.
Calciumdependent block of P2X7 receptor channel function is allosteric.
J. Gen. Physiol., 138:(4):437452.
[PubMed]

A. Khadra, M. Pietropaolo, G. T. Nepom, and A. Sherman. 2011.
Investigating the role of T cell avidity and killing efficacy in relation to type 1 diabetes prediction
PLoS One, 6(5):e14796.
[PubMed]

M. Watts, J. Tabak, C. Zimliki, A. Sherman, and R. Bertram. 2011.
Slow variable dominance and phase resetting in phantom bursting.
J. Theor. Biol. 276:218228.
[PubMed]
[XPP Files]

A. Liu, A. Sonmez, G. Yee, M. Bazuine, M. Arroyo, A. Sherman, T. McLaughlin, G. Reaven, s. Cushman, P. Tsao. 2010.
Differential adipogenic and inflammatory properties of small adipocytes in Zucker Obese and Lean rats.
Diab Vasc Dis Res., 7(4):3118.
[PubMed]

Z. Yan, A. Khadra, S. Li, M. Tomic, A. Sherman, and S. S. Stojilkovic. 2010.
Experimental characterization and mathematical modeling of P2X7 receptor channel gating.
J Neurosci. 30(42):1421324.
[PubMed]

R. Kursawe, M. Eszlinger, D. Narayan, T. Liu, M. Bazuine, A. M.
G. Cali, M. Shaw, B. Pierpont, G. I. Shulman, S. W. Cushman, A. Sherman, and S. Caprio. 2010.
Cellularity and adipogenic profile of the abdominal subcutaneous adipose tissue from obese
adolescents: association with insulin resistance and hepatic steatosis.
Diabetes, 59(9):228896.
[PubMed]

B. E. Peercy and A. S. Sherman. 2010.
How pancreatic betacells distinguish long and shorttime scale cAMP signals.
Biophys. J., 99(2):398406
[PubMed]
[XPP and Matlab Files]

M. J. Merrins, B. Fendler, M. Zhang, A. Sherman, R. Bertram, and L. S. Satin. 2010.
Metabolic oscillations in pancreatic islets depend on the intracellular Ca^{2+} level but not Ca^{2+} oscillations,
Biophys. J., 99:(1)7694.
[PubMed]
[XPP Files]

K. TsanevaAtanasova, H. M. Osinga, T. Riess, and A. Sherman. 2010.
Full system bifurcation analysis of endocrine bursting models.
J. Theor. Biol., 264:11331146.
[PubMed]

T. McLaughlin, G. Yee, T. Liu, F. Abbasi, C. Lamendola, G. Reaven, P. Tsao, S. W. Cushman, and A. Sherman. 2010.
Pioglitazone increases the proportion of small cells in human subcutaneous abdominal adipose tissue.
Obesity, 18(5):92631.
[PubMed]

T. McLaughlin, A. Deng, G. Yee, C. Lamendola, G. Reaven, P. S. Tsao, S. W. Cushman, and A. Sherman. 2010.
Inflammation in subcutaneous adipose tissue: relationship to adipose cell size.
Diabetologia 53(2):369377.
[PubMed]
[Commentary]

C. S. Nunemaker, J. F. Dishinger, S. B. Dula, R. Wu, M. M. Merrins, K. R. Reid, A. Sherman, R. T. Kennedy, and L. S. Satin. 2009.
Glucose metabolism, islet architecture, and genetic homogeneity in imprinting of [C
a^{2+}]_{i} and insulin rhythms in mouse islets.
PloS One, 4(12):e8428.
[PubMed]

A. Liu, T. McLaughlin, T. Liu, A. Sherman, G. Yee, F. Abbasi, C. Lamendola, J. Morton, S. W. Cushman, G. M. Reaven, and P. S. Tsao. 2009
Differential Intraabdominal Adipose Tissue Profiling in Obese, Insulinresistant Women.
Obes. Surg., 19(11):156473.
[PubMed]

P. Goel and A. Sherman. 2009.
The geometry of bursting in the dual oscillator model of pancreatic betacells.
SIAM Journal on Applied Dynamical Systems, 8(4):16641693.
[Journal Web Site]

V. Matveev, R. Bertram, and A. Sherman. 2009.
Ca^{2+} current vs. Ca^{2+} channel cooperativity of exocytosis.
J. Neurosci., 29(39):1219612209.
[PubMed]

K. TsanevaAtanasova and A. Sherman. 2009.
Accounting for nearnormal glucose sensitivity in Kir6.2[AAA] transgenic mice.
Biophys. J. 97(9):240918.
[PubMed]

P. Goel, A. Sherman, and A. Friedman. 2009.
Multiscale modeling of electrical and intracellular activity in the pancreas: The islet tridomain equations.
Multiscale Model. Simul., 7(4):16091642.
[Journal Web Site]

M. G. Pedersen and A. Sherman. 2009.
Newcomer insulin secretory granules as a highly calciumsensitive pool.
PNAS 106(18):74326.
[PubMed]

T. McLaughlin, A. Deng, O. Gonzales, M. Aillaud, G. Yee, C. Lamendola, F. Abbasi, A. J. Connolly, A. Sherman, S. W. Cushman, G. Reaven, P. S. Tsao. 2008.
Insulin resistance is associated with a modest increase in inflammation in subcutaneous adipose tissue of moderately obese women.
Diabetologia, 51:23038.
[PubMed]

M. Zhang, B. Fendler, B. Peercy, P. Goel, R. Bertram, A. S. Sherman, and L. S. Satin. 2008.
Long lasting synchronization of calcium oscillations by cholinergic stimulation in isolated pancreatic islets.
Biophys. J., 95:46764688.
[PubMed]
[XPP Files]

Y. D. Chen, S. Wang, A. Sherman. 2008.
Identifying the targets of the amplifying pathway for insulin secretion in pancreatic betacells by kinetic modeling of granule exocytosis.
Biophys. J. 95(5):222641.
[PubMed]
[XPP Files]

J. V. Stern, H. M. Osinga, A. LeBeau, and A. Sherman. 2008.
Resetting behavior in a model of bursting in secretory pituitary cells:
Distinguishing plateaus from pseudoplateaus.
Bull. Math. Biol., 70(1):6888.
[PubMed]
[XPP Files]

K. TsanevaAtanasova, A. Sherman, F. van Goor, and S. S. Stojilkovic. 2007.
Mechanism of spontaneous and receptorcontrolled electrical activity in pituitary somatotrophs: Experiments and theory.
J. Neurophysiol. 98(1):13144.
[PubMed]
[XPP File]

T. McLaughlin, A. Sherman, P. Tsao, O. Gonzalez, G. Yee, C. Lamendola, G. M. Reaven, and S. W. Cushman. 2007.
Enhanced proportion of small adipose cells in insulinresistant versus insulinsensitive obese individuals implicates impaired adipogenesis.
Diabetologia, 50(8):170715.
[PubMed]
 H. L. Ong, X. Liu, K. TsanevaAtanasova, B. B. Singh, B.
C. Bandyopadhyay, W. D. Swaim, J. T. Russell, R. S. Hegde,
A. Sherman, and I. S. Ambudkar. 2007.
Relocalization of STIM1 for activation of storeoperated Ca^{2+} entry is determined by the depletion of subplasma membrane endoplasmic reticulum Ca^{2+}
store.
J. Biol. Chem., 282(16):1217685.
[PubMed]
 R. Bertram, L. S. Satin, M. Gram Pedersen, D. S. Luciani, and A.
Sherman, 2007.
Interaction of glycolysis and mitochondrial respiration in metabolic
oscillations of pancreatic islets.
Biophys. J., 92(5):154455.
[Pubmed]
[XPP files]
 V. Matveev, R. Bertram, and A. Sherman, 2006.
Residual bound Ca^{2+} can account for the effects of Ca^{2+} buffers on synaptic facilitation.,
J. Neurophysiol. 96(6):338997
[Pubmed]
[CalC Scripts]
 R. Bertram, M. Gram Pedersen, D. S. Luciani, and A. Sherman, 2006.
A simplified model for mitochondrial ATP production,
J. Theor. Biol., 243(4):57586.
[Pubmed]
[XPP file]
 C. S. Nunemaker, R. Bertram, A. Sherman, K. TsanevaAtanosova, C. R. Daniel, and L. S. Satin. 2006.
Glucose modulates Ca^{2+} oscillations in pancreatic islets via ionic and glycolytic mechanisms,
Biophys. J., 91:20822096.
[Pubmed]
[XPP Files]
 K. TsanevaAtanasova, C. L. Zimliki, R. Bertram, and A. Sherman, 2006.
Diffusion of calcium and metabolites in pancreatic islets: Killing oscillations with a pitchfork,
Biophys. J., 90:34343446.
[PubMed]
[XPP Files]
 C. S. Nunemaker, M. Zhang, D. H. Wasserman, O. P. McGuinness, A. C. Powers, R. Bertram, A. Sherman, and L. S. Satin, 2005.
Individual mice can be distinguished by the period of their islet calcium oscillations: Is there an intrinsic islet period which is imprinted in vivo?
Diabetes, 54:35173522
[PubMed]
 M. G. Pedersen, R. Bertram, and A. Sherman. 2005.
Intra and InterIslet Synchronization of Metabolically Driven Insulin Secretion,
Biophys. J., 89:107119.
[PubMed]
[XPP Files]
 R. Bertram and A. Sherman. 2004.
Filtering of calcium transients by the endoplasmic reticulum in pancreatic
betacells,
Biophys. J., 87:37753785.
[PubMed]
[XPP Files]
 R. Bertram, L. Satin, M. Zhang, P. Smolen, and A. Sherman. 2004.
Calcium and glycolysis mediate multiple bursting modes in
pancreatic islets,
Biophys. J., 87:30743087.
[PubMed]
[XPP Files and Errata]
 R. Bertram and A. Sherman. 2004.
A calcium based phantom bursting model for pancreatic betacells,
Bull. Math. Biol., 66:13131344.
[PubMed]
[XPP Files and Animations]
 C. Zimliki, D. Mears, and A. Sherman. 2004.
Three roads to islet bursting: Emergent oscillations in coupled
phantom bursters,
Biophys. J., 87:193206.
[PubMed]
[XPP file]
 V. Matveev, R. S. Zucker, and A. Sherman. 2004.
Facilitation through buffer saturation: Constraints on endogenous
buffering properties,.
Biophys. J. 86:26912709.
[PubMed]
[Calcium Calculator Software]
[CalC Scripts]
 M. Zhang, P. Goforth, A. Sherman, R. Bertram, and L. S. Satin. 2003.
The Ca^{2+} dynamics of isolated mouse betacells and islets: Implications
for mathematical models, . Biophys. J. 84:28522870.
[PubMed]
[XPP Files]
 A. R. Sedaghat, A. Sherman, and M. J. Quon. 2002.
A mathematical model of metabolic insulin signaling pathways,
Am. J. Physiol. (Endocrinol. Metab.), 283:E1084E1101.
[PubMed
] [Supplementary Material: XPP/WinPP Differential
Equation Files]
 P. B. Goforth, R. Bertram, F. A. Khan, M. Zhang, A. Sherman, and L. S.
Satin. 2002. Calciumactivated K^{+} channels of mouse pancreatic betacells
are controlled by both store and cytoplasmic Ca^{2+}. J. Gen. Physiol.,
120:307322. [PubMed]
[XPP Files]

V. Matveev, A. Sherman, and R. S. Zucker. 2002.
New and Corrected Simulations of Synaptic Facilitation,
Biophys. J., 83:136873.
[PubMed]
[Simulation Software]
[CalC Scripts]

G. de Vries and A. Sherman. 2001.
From spikers to bursters via coupling: Help from heterogeneity, Bull.
Math. Biol., 63:371391.
[PubMed]

G. D. Smith, L.X. Dai, R. Miura, and A. Sherman. 2001.
Asymptotic analysis of equations for the buffered diffusion of
intracellular calcium.
SIAM J. Applied Math., 61:18161838.
[The Journal]
[Matlab Files]

A. P. LeBeau, F. Van Goor, S. S. Stojilkovic, and A. Sherman. 2000.
Modeling of membrane excitability in gonadotropinreleasing hormonesecreting hypothalamic neurons regulated by Ca2+mobilizing and adenylyl cyclasecoupled receptors. J. Neurosci., 20:92909297.
[PubMed]
[Flash Animation]

G. de Vries and A. Sherman. 2000. Channel sharing in pancreatic
betacells revisited: Enhancement of emergent bursting
by noise. J. Theor. Biol., 207:513530.
[PubMed]

R. Bertram, J. Previte, A. Sherman, T. A. Kinard, and L. S. Satin.
2000. The phantom burster model for pancreatic betacells.
Biophys. J., 79:28802892.
[PubMed]
[Flash Animation]
[XPP File]

F. Van Goor, A. P. LeBeau, L. Z. Krsmanovic, A. Sherman,
K. J. Catt, and S. S. Stojilkovic. 2000. Amplitudedependent
spikebroadening in immortalized GnRH neurons.Biophys. J.,
79:13101323.
[PubMed]

T. A. Kinard, G. de Vries, A. Sherman, and L. S. Satin. 1999.
Modulation of the bursting properties of single mouse
pancreatic betacells by artificial conductances.
Biophys. J., 76:14231435.[PubMed]

R. Bertram, G. D. Smith, and A. Sherman. 1999.
A modeling study of the effects of overlapping Ca^{2+} microdomains
on neurotransmitter release.
Biophys. J., 76:735750.
[PubMed]

G. de Vries, H.R. Zhu, and A. Sherman. 1998.
Diffusively coupled bursters: Effects of heterogeneity.
Bull. Math. Biol., 60:11671200.
[PubMed]
[Mathematica Files]

R. Bertram and A. Sherman. 1998. Population dynamics of synaptic
release sites. SIAM J. Applied Math., 58:142169.
[The Journal]
[MathSciNet]

D. Mears, N. F. Sheppard, Jr., I. Atwater, E. Rojas, R. Bertram, and
A. Sherman. 1997. Evidence that calcium releaseactivated current mediates
transient glucoseinduced electrical activity in the pancreatic betacell.
J. Membr. Bio., 155:4759. [PubMed]

R. Bertram, A. Sherman, and E. Stanley. 1996. The single domain/bound
calcium hypothesis of transmitter release and facilitation. J. Neurophysiol.,
75:19191931. [PubMed]

R. Bertram, P. Smolen, A. Sherman, D. Mears, I. Atwater, F. Martin,
and B. Soria. 1995. A role for calciumrelease activated current (CRAC)
in cholinergic modulation of electrical activity in pancreatic betacells.
Biophys. J. 68:23232332. [PubMed]

R. Bertram, M. Butte, T. Kiemel, and A. Sherman. 1995. Topological
and phenomenological classification of bursting mechanisms. Bull. Math.
Biol. 57:413439.
[PubMed]
[XPP File]

A. Sherman, L. Xu, and C. Stokes. 1995. Estimating and eliminating
junctional current in coupled cell populations by leak subtraction. A computational
study. J. Membr. Biol., 143:7987. [PubMed]
(Joint with experimental paper: E. Rojas, C. Stokes, D. Mears, and I. Atwater.
1995. Single microelectrode voltageclamp measurements of pancreatic
betacell membrane ionic currents in intact mouse islets of Langerhans.
J. Membr. Biol. 143:6577). [PubMed]
 A. Sherman and M. Mascagni. 1994. A gradient random walk method for
twodimensional reactiondiffusion equations. SIAM J. Sci. Comput.
15:12801293.
[Web of Science]
[MathSciNet]
 P. Smolen and A. Sherman. 1994. Phaseindependent resetting in relaxation
and burst oscillators. J. Theor. Biol. 169:339348. [PubMed]
 A. Sherman. 1994. Antiphase, asymmetric, and aperiodic oscillations
in excitable cells I. Coupled bursters. Bull. Math. Biol. 56:811835.
[PubMed]
 P. Smolen, J. Rinzel, and A. Sherman. 1993. Why pancreatic islets
burst but single betacells do not: The heterogeneity hypothesis. Biophys.
J. 64:16681680. [PubMed]
 A. Sherman and J. Rinzel. 1992. Rhythmogenic effects of weak electrotonic
coupling in neuronal models. Proc. Natl. Acad. Sci. USA. 89:24712474.
[PubMed]
[XPP Files]
 A. Sherman and J. Rinzel. 1991. Model for synchronization of pancreatic
betacells by gap junction coupling. Biophys. J. 59:547559.
[PubMed]

A. Sherman, J. Keizer, and J. Rinzel. 1990. Domain model for Ca^{2+}
inactivation of Ca^{2+} channels at low channel density. Biophys. J. 58:985995.
[PubMed]
[XPP File]

P. B. Carroll, A. Sherman, R. Ferrer, A. C. Boschero, J. Rinzel, and
I. Atwater. 1990. Modulation of the frequency of glucosedependent bursts
of electrical activity by HCO3/CO2 in rodent pancreatic betacells. Experimental
and theoretical results. Eur. Biophys. J. 18:7177. [PubMed]

A. Sherman, J. Rinzel, and J. Keizer. 1988. Emergence of organized
bursting in clusters of pancreatic betacells by channel sharing. Biophys.
J. 54:411425. [PubMed]
[XPP File]

A. S. Sherman and C. S. Peskin. 1988. Solving the HodgkinHuxley
equations by a random walk method. SIAM J. Sci. and Stat. Comput. 9:170190.
[The Journal]

A. S. Sherman and C. S. Peskin. 1986. A Monte Carlo method for scalar
reaction diffusion equations. SIAM J. Sci. and Stat. Comput. 7:13601372.
[The Journal]
Invited Reviews

R. Bertram, L. S. Satin, and A. S. Sherman. 2018.
Closing in on the mechanisms of pulsatile insulin secretion.
Diabetes, 67:351359.
[PubMed]

P. A. Fletcher, A. Sherman, and S. S. Stojilkovic. 2018.
Common and diverse elements of ion channels and receptors underlying electrical activity in endocrine pituitary cells.
Molecular and Cellular Endocrinology, 463:23  36.
[PubMed]

L. S. Satin, P. C. Butler, J. Ha, and A. Sherman. 2015.
Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes.
Journal of Molecular Aspects of Medicine, 42:6177.
[PubMed]

V. Matveev, R. Bertram, and A. Sherman, 2011.
Calcium cooperativity of exocytosis as a measure of Ca^{2+} channel domain overlap.
Brain Research Reviews, 1398:126128.
[PubMed]

A. Sherman, 2010.
Lessons from Models of Pancreatic beta Cells for Engineering Glucosesensing Cells.
Math. Biosci., 227:1219.
[PubMed]

R. Bertram, A. Sherman, and L. S. Satin, 2007.
Metabolic and electrical oscillations: Partners in controlling pulsatile insulin secretion.
Am. J. Physiol. Endocrinol. Metab. 293:890900.
[PubMed]
 G. de Vries and A. Sherman. 2005.
Beyond Synchronization: Modulatory and Emergent Effects
of Coupling in SquareWave Bursting
in "Bursting: The Genesis of Rhythm in the Nervous System",
World Scientific, London, pp. 243272.
[Publisher's
Site]
 R. Bertram and A. Sherman. 2005.
Negative Calcium Feedback: The Road from ChayKeizer
in "Bursting: The Genesis of Rhythm in the Nervous System",
S. Coombes and P. Bressloff, eds.,
World Scientific, London, pp. 1948.
[Publisher's Site
]
 A. Sherman and R. Bertram. 2005.
Integrative Modeling of the Pancreatic betaCell.
in "Wiley Interscience Encyclopedia of Genetics, Genomics,
Proteomics, and Bioinformatics",
Part 3 Proteomics, M. Dunn, ed.,
Section 3.8 Systems Biology, R. L. Winslow, ed.,
John Wiley & Sons, Ltd.
DOI: 10.1002/047001153X.g308213.
[OnLine Book]
[XPP Files]
 A. Sherman. 1996. Contributions of modeling to understanding stimulussecretion
coupling in pancreatic betacells. Am. J. Physiol. 271 (Endocrinol.
Metab. 34): E362E372. [PubMed]

A. Sherman. 1995. Theoretical aspects of synchronized bursting in betacells,
in Pacemaker Activity and Intercellular Communication, J. D. Huizinga,
ed., CRC Press, Boca Raton, pp. 323337.
Book Chapters & Other Reviews

A. Sherman. 2016.
Endoplasmic reticulum and plasma membranedriven calcium oscillations,
in "Computational Neuroendocrinology" (WileyINF Masterclass in Neuroendocrinology Series), D. J. MacGregor and G. Leng, eds.,
John Wiley & Sons, Chichester, UK,
p. 112141.
[The Book]

R. Bertram, A. Sherman, and L. S. Satin. 2013.
Electrical, Calcium, and Metabolic Oscillations in Pancreatic Islets,
in "The Islets of Langerhans", 2nd edition, M. S. Islam, ed.,
SpringerVerlag, Berlin, p. 453474.

R. Bertram, A. Sherman, and L. S. Satin. 2010.
Electrical Bursting, Calcium Oscillations, and Synchronization of Pancreatic Islets,
in "The Islets of Langerhans", M. S. Islam, ed.,
SpringerVerlag, Berlin,
(Adv Exp Med Biol, 654:26179).
[PubMed]
[The Chapter]
[The Book]

R. Bertram, K. Wierschem, M. Zhang, P. Goforth, A. Sherman, and L. S. Satin. 2002.
Phantom bursting in pancreatic islets: A potential role for insulin feedback,
in "Recent Research Developments in Biophysics", S. G. Pandalai, ed.,
Transworld Research Network, Vol. 1, pp. 3151.
 A. Sherman, Y.X. Li, and J. Keizer. 2002. Whole Cell Models in
"Computational Cell Biology", C. Fall, E. Marland, J. Wagner, and J.
Tyson , eds., SpringerVerlag, New York, pp. 101  139.
[Web Site for the Book]
 R. Bertram and A. Sherman. 2000. Dynamical complexity
and temporal plasticity in pancreatic betacells. J. Biosc.,
25:197209.
[PubMed]
 M. V. Mascagni and A. S. Sherman. 1998. Numerical methods for neuronal
modeling, in "Methods in Neuronal Modeling," I. Segev and C. Koch,
eds., MIT Press, Cambridge, pp.569606.
[The Book] [Supplementary Material]
 A. Sherman and P. Smolen. 1997. Computer modeling of
heterogeneous betacell populations,
in "Physiology and Pathophysiology of the Islets of Langerhans",
B. Soria, ed., Plenum Press, New York, pp. 275284.
[PubMed]
[Abstract]
 A. Sherman. 1997. Calcium and membrane potential oscillations in
pancreatic betacells, in "Case Studies in Mathematical Modeling 
Ecology, Physiology, and Cell Biology", H. G. Othmer, F. R. Adler, M.
A. Lewis, and J. C. Dallon, eds., PrenticeHall, New Jersey, p. 199  217.
[The Book]
[Models
and Exercises]
 J. Rinzel, A. Sherman, and C. L. Stokes. 1992. Channels, coupling,
and synchronized rhythmic bursting activity. in "Analysis and Modeling
of Neural Systems", F. H. Eeckman, ed., Kluwer Academic Publishers, Boston,
pp. 2946.
 A. Sherman, P. Carroll, R. Santos, and I. Atwater. 1990. Glucose
dose response of pancreatic betacells: Experimental and theoretical results,
in "Transduction in Biological Systems", J. Bacigalupo, C. Hidalgo,
E. Jaimovich, and J. Vergara, eds., Plenum Press, New York, pp. 123141.

A. Sherman and J. Rinzel. 1989. Collective properties of insulin secreting
cells, in "Cell to Cell Signalling: From Experiments to Theoretical
Models", A. Goldbeter, ed., Academic Press, London, pp. 6175.
Commentary

L. S. Satin, J. Ha, and A. S. Sherman. 2016.
Islets Transplanted into the Eye: Do They Improve Our Insight into Islet Adaptation to Insulin Resistance?
Diabetes, 65(9):24702.
[PubMed]
[Commentary on Chen et al, Diabetes. 2016 65(9):267685]

A. Sherman. 2011.
Dynamical systems theory in physiology.
J. Gen. Physiol. 138:1319.
[PubMed]
[Commentary on Cha et al, J. Gen. Physiol. 2011 138(1):394765.]
[Cover Art]
[XPP Files]
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Last updated 07/07/05