Glucose Sensing with Combined Metabolic Electrical Model

This is supplementary material for:

C. S. Nunemaker, R. Bertram, A. Sherman, K. Tsaneva-Atanosova, C. R. Daniel, and L. S. Satin. 2006. Glucose modulates Ca²⁺ oscillations in pancreatic islets via ionic and glycolytic mechanisms, Biophys. J., 91:2082--2096. [Pubmed]

The models in this paper show that the diverse responses to glucose seen in pancreatic islets can be accounted for by a model combining glycolytic and ionic (calcium) mechanisms.

XPP files by figure:

• Fast Oscillation; reduction in silent phase (Figure 9A)
• Fast Oscillation; increase in active phase (Figure 9B)
• Slow Oscillation (Figure 10A)
• Compound Oscillation (Figure 10B)
• Regime Change: Increase in glucose converts from fast electrical to slow metabolic (Figure 11)
• Reverse Regime Change: Model predicts that lowering glucose converts fast electrical to slow metabolic (confirmed experimentally in Fig. 12C, D in paper) (Figure 12A, B)

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